Given the signiﬁcant disability, morbidity and mortality associated with depression, the promising recent trials of ketamine highlight a novel intervention.
Please help me identify what the quantitative research design is for the following study. There are four main types of Quantitative research: 1. Descriptive 2. Co relational 3. Causal-Comparative/Quasi-Experimental 4. Experimental Research.
Given the signiﬁcant disability, morbidity and mortality associated with depression, the promising recent trials of ketamine highlight a novel intervention. A meta-analysis was conducted to assess the efﬁcacy of ketamine in comparison with placebo for the reduction of depressive symptoms in patients who meet criteria for a major depressive episode.
Method: Two electronic databases were searched in September 2013 for English-language studies that were ran-domized placebo-controlled trials of ketamine treatment for patients with major depressive disorder or bipolar depression and utilized a standardized rating scale. Studies including participants receiving electroconvulsive ther-apy and adolescent/child participants were excluded. Five studies were included in the quantitative meta-analysis. Results: The quantitative meta-analysis showed that ketamine signiﬁcantly reduced depressive symptoms. The overall effect size at day 1 was large and statistically signiﬁcant with an overall standardized mean difference of 1.01 (95% conﬁdence interval 0.69–1.34) (Pb.001), with the effects sustained at 7 days postinfusion. The heteroge-neity of the studies was low and not statistically signiﬁcant, and the funnel plot showed no publication bias. Conclusions: The large and statistically signiﬁcant effect of ketamine on depressive symptoms supports a promising, new and effective pharmacotherapy with rapid onset, high efﬁcacy, and good tolerability.